PEA safeguards versus bacterial infection by using innate immune modulation involving MCs, macrophages and microglia. Prophylactic PEA at a dose of 0.one mg/kg entire body excess weight prolonged survival rate and diminished neuro-inflammation in an aged murine bacterial meningitis model, while in the absence of antibiotics [42].Idea of exogenous P
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2016a). This smaller sized raise was proportionate to the smaller sized peak of PEA levels detected in human volunteers compared with beagle dogs. This variation, subsequently, is often attributable to the decrease complete level of PEA acutely administered to human volunteers (about ∼five vs. thirty mg·kg−one in pet dogs) and to the fact tha